The 4U framework encourages entrepreneurs to deeply understand their customers' challenges and needs by identifying what is Unavoidable, Urgent, Unworkable, and Underserved in their lives. Using real-world examples, it illustrates how companies like Uber, Instacart, Slack, and Airbnb have successfully applied this approach to address pressing customer issues, such as the need for reliable transportation or quick grocery delivery. This methodology is key to uncovering unmet needs and creating innovative solutions that resonate with the target market from the start. Entrepreneurs are urged to become genuinely inquisitive about their customers to discover multiple aspects of the 4Us, ultimately leading to the development of compelling offerings and the growth of their startups.