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Oxycodone can cause various side effects, both short-term and long-term. Short-term side effects include nausea, vomiting, constipation, drowsiness, dry mouth, and respiratory depression

In addition, if the drug is used off-label by crushing the tablet and dissolving it for injection, it may precipitate severe opiate withdrawal symptoms due to the much higher bioavailability of intravenous naloxone

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