Fat Cells Produce Estrogen: Fat cells, especially those in the abdominal area, are not just storage units for excess calories; they also produce estrogen. As the ovaries reduce their estrogen production during perimenopause and menopause, the body might try to compensate by producing more fat cells, thereby creating more sites for estrogen production.
Estrogen and Insulin: Estrogen dominance can impact the way the body responds to insulin, the hormone responsible for regulating blood sugar. When cells become more resistant to insulin, the body needs to produce more insulin to get the same effect. High insulin levels can lead to increased fat storage, especially in the abdominal area.
Liver Function: Estrogen dominance can influence liver function. The liver produces a protein called sex hormone-binding globulin (SHBG) which binds excess hormones, including estrogen, and removes them from circulation. An overloaded or under-functioning liver might not produce enough SHBG, which can exacerbate estrogen dominance. Additionally, the liver is essential for detoxifying excess hormones, and an impaired liver can further contribute to hormonal imbalances.
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