Next R&D - AI & Active Aging

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Usecase: Active Aging, The Next Wave
Usecase: Active Aging, The Next Wave

AI-enabled R&D for smarter Frailty interventions (e.g. home care, risk mitigation, and alternative therapeutic pathways)

Frailty is an age related condition, impacting a growing number of people globally

By 2050, approximately 21.3% of the global population will be 60 years or older, up from 9.2% in 1990. Frailty, a clinical syndrome characterized by marked vulnerability due to decline in reserve and function across multiple physiologic systems, is common among older people.

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Source: Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults, 2019⁠

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The prevalence of Frailty is a growing cause of concern for quality of life as well as associated risks in health outcomes post-treatment.

... 7 to 12 percent of Americans age 65 and older are considered frail. Risk rises with age—from one in 25 people between ages 65 and 74 to one in four of those older than age 84.

... In a study of 594 older adults, Johns Hopkins researchers have found that frailty doubles the risk of surgical complications, lengthens hospital stays, and increases the odds of leaving independence behind after a surgical procedure by as much as twentyfold.

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Source: Stay Strong: Four Ways to Beat the Frailty Risk, Johns Hopkins Medicine⁠

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Interventions to tackle Frailty require deeper discovery and risk management R&D

Over the last decade Frailty has become an important research area, with expectations of more interventions that can help people age better. However, the explosion of data and literature can be overwhelming. A recent conference on the topic, reveals the complex causal pathways implicated in the manifestation of frailty.

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Source: Summary from the American Geriatrics Society Conference on Frailty in Older Adults 2006⁠

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The literature relevant to the various treatment and clinical pathways is exploding – many of them (e.g. clotting, mitochondrial deletions, weight loss) not directly tagged as Frailty related clinical research. A real challenge for therapeutic discovery and risk mitigation R&D.

Next Wave AI has proven results — finding needles in a haystack — faster, for less

In a proof of concept to assist breast cancer researchers, human-in-loop REACH software helped extend the PC (

PathwayCommons⁠

) human-curated pathways dataset, with fragments extracted from all papers in the Open Access subset of

PubMed⁠

(using over a million publications).

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Source: Large-scale machine reading discovers new cancer-driving mechanisms, 2018⁠

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The network of software enabled pathways was 12X larger than the industry standard dataset. Enabling the identification of seven new "driver genes" for breast cancer. Comparable results have been replicated in other clinical areas.

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Source: Large-scale machine reading discovers new cancer-driving mechanisms, 2018⁠

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We intend to customize and extend the underlying DARPA technology to focus on interventions and pathways connected to Frailty. Aiming to use Next Wave AI to help people around the world stay active, develop resilience and age with a better quality of life.

THE ASK

We are seeking client partners to team with on R&D and commercialization

This aligns with Active Aging. A key priority area for P&G Ventures.

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Source: P&G Ventures Checklist⁠

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Over 90% of the Boomer generation already is (or will be) aging at home. Aging on their own terms. Holding onto their home and car keys unlike the generations before them who routinely shuffled into retirement communities and accepted being “elderly” and the lifestyle that went with it. ... systemic conundrum of how our country and wallets will sustain ... the “Crisis of Care” ... so far, it’s an unsolved mystery.

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Source: Design the World You Want to Age In, Noel Gauthier, Senior Designer, P&G Ventures⁠

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Usecase: Active Aging, The Next WaveUsecase: Active Aging, The Next Wave