B3-OLX Product Briefs

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Anti Inflammatory & Scarring


B3 Owner - Alex
OLX Lead - To Be Filled by Martha
Team - To Be Filled by Martha


Development of acne scar (atrophic) healing treatment with improved efficacy in Scar treatment and prevention compared to existing market prescription comparisons.

Target Products - Prioritized
[Acne] OTC Acne Treatment (Strong/Sensitive) (IL1B, IL17)
[Acne] Scar Prevention Moisturizer (1L1B, IL17, MMP2)
[Acne] Compounded Tretinoin Treatment (IL1B, IL17)
[Color] Scar Healing Primer


Efficacy - Comparable efficacy (Matching efficacy as measured by lesion count improvement after 8 and 12 weeks) to Compound Tretinoin 0.025 efficacy, focused on three main endpoints. Molecule discovery and prioritization should focus on all three.
Reactive (Corrective) improvement of existing atrophic scars
Prevention of new acne scars formation:
Normalized tissue formation / matrix remodeling / deposition of collagen
Inflammation reduction for active inflammatory lesions (papules, pustules, and nodules)
Normalized inflammatory response
Tolerability - Tolerable by sensitive skin
Prevention / inflammation reduction candidate molecules:
Cannot cause or exacerbate further inflammation
Must be less sensitizing (dryness, redness) than Retinol

Formulation Constraints - Ability to be formulated with/in:
Silicone - For usage with Primer / Scar filling formulations
Range of pH systems (3.5 - 6.5) - For eventual usage in OTC product line w/ Salicylic acid as well as pH-balanced moisturizers
Salicylic acid - Does not lead to crystallization / degradation of SA specifically


1 .Scar Prevention Moisturizer -
@Alex Kaplan

Still working on finalizing market research & brief (expected March)

2. Stretch Marks Treatment -
@Tom Amsterdam

Instant / short term firming and tightening effects - leveraging optical diffusers
Instant / short term smoothing effects - leveraging film-forming ingredients
Long term effect improving and stretch marks BOTH Striae Rubrae and Striae Albae Stretch Marks​
Promotes a Contoured, Toned and Slimmer Belly - Uses actives like peptides, algae, or other to target adipose tissue and cellulite in the belly area to actively firm over time and stimulate collagen and elastin production​
Deep Hydration and Plumping - Hydrates, softens and improves texture, with a particular focus on nurturing skin that stretches out during pregnancy (through shea butter, hyaluronic acid, and / or others). Moisturizes without any greasy, tacky feel, designed to be well and quickly absorbed into the skin
Form Factor -
Lightweight cream, easily spreadable, absorbs quickly (non-greasy, non-staining)
Fill Size & Cadence
100ml, 1 month cadence
Daily usage (1-2x/day)
Light and absorbs quickly
Leaves skin feeling glowing
Seamlessly layers with other skincare products or under makeup (no piling)
Does not burn the eyes
Light, natural (floral or fruity), include only if non-irritating, pregnancy safe
Paraben-free, Cruelty-free, Non-comedogenic, Hypo-allergenic, Sulfate-free, Phthalate-free, dyes/synthetic color-free​. Suitable for sensitive skin​
Pregnancy Safe: all ingredients must be safe for use during pregnancy
Nice To Have:
Natural oils to soothe and hydrate skin (like calendula, sunflower, avocado or others)​
Instant optical smoothing effects delivered through light diffusers ingredient (e.g., dimethicone, silica, cellulose, ethylene, mica)
Instant tightening effects delivered through tightening film-forming ingredients (e.g., sodium acryloydimethyl taurate copolymer, pullan, acrylates copolymer)
Vasoconstrictor Firming & Tightening Actives - Must include vasoconstrictors (no caffeine or equivalent) that are pregnancy safe to provide firming/tightening benefits​​
Targets BOTH Striae Rubrae and Striae Albae Stretch Marks
Uses centella asiatica, glycolic acid (<= 10%), and vitamin E to target both Striae Rubrae and Striae Albae Stretch Marks

3. Acne OTC Treatment -
@Alex Kaplan

Clears acne blemishes and prevents new breakouts
Controls oiliness without disrupting the skin barrier
Gently exfoliates the skin’s surface—clears pores, removes dead skin cells, helps uneven skin tone/texture, brightens, reduces appearance of scars
Gentle enough for daily use, even on sensitive skin, with soothing ingredients to mitigate irritation
Formulation parameters
Texture: Sheer weightless serum—not too runny where it slides off hands/face, but not too thick where it is hard to spread. Does not clump. Non-greasy, non-sticky, fast-absorbing texture.
Experience: Light, and absorbs quickly without drying out the skin. Leaves skin feeling moisturized, but not greasy or oily; no residue. Seamlessly layers with other skincare products or under makeup (no piling). Does not burn the eyes.
Must-have ingredients
1-2% Salicylic Acid (can be encapsulated to improve irritation profile or solubility / pH range)
Soothing/hydrating ingredients to counteract irritation and TEWL
Nice-to-have ingredients
Niacinimide: Include, as long as it does not compromise performance of Salicylic Acid
Cosmetic anti-irritants (to hydrate, soothe, and minimize irritation): E.g., allantoin, madecassoside, cica, hyaluronic acid, glycerin, aloe
Plant antioxidants: E.g., green tea, chamomile, willowherb, licorice root, etc.?
Paraben-free, Cruelty-free, Drying alcohol-free, Fragrance-free, Hypo-allergenic, Sulfate-free, Silicone-free, Phthalate-free, dyes/synthetic color-free​

Scent: Neutral (not medicinal nor chemical)

4. Scar Healing + Preventing Treatment -
@Alex Kaplan

Still working on finalizing market research & brief (expected March)

5. Scar Defense Primer -
@Tom Amsterdam

6. Compounded Tretinoin -
@Akhila Moturu

Implementation Plan

Supporting Resources

Stretch Marks Research & Briefs -
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