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Anti Inflammatory & Scarring

Team

B3 Owner - Alex

OLX Lead - To Be Filled by Martha

Team - To Be Filled by Martha

Goal

Development of acne scar (atrophic) healing treatment with improved efficacy in Scar treatment and prevention compared to existing market prescription comparisons.

Target Products - Prioritized

[Acne] OTC Acne Treatment (Strong/Sensitive) (IL1B, IL17)

[Acne] Scar Prevention Moisturizer (1L1B, IL17, MMP2)

[Acne] Compounded Tretinoin Treatment (IL1B, IL17)

[Color] Scar Healing Primer

Requirements

Efficacy - Comparable efficacy (Matching efficacy as measured by lesion count improvement after 8 and 12 weeks) to Compound Tretinoin 0.025 efficacy, focused on three main endpoints. Molecule discovery and prioritization should focus on all three.

Reactive (Corrective) improvement of existing atrophic scars

Prevention of new acne scars formation:

Normalized tissue formation / matrix remodeling / deposition of collagen

Inflammation reduction for active inflammatory lesions (papules, pustules, and nodules)

Normalized inflammatory response

Tolerability - Tolerable by sensitive skin

Prevention / inflammation reduction candidate molecules:

Cannot cause or exacerbate further inflammation

Must be less sensitizing (dryness, redness) than Retinol

Formulation Constraints - Ability to be formulated with/in:

Silicone - For usage with Primer / Scar filling formulations

Range of pH systems (3.5 - 6.5) - For eventual usage in OTC product line w/ Salicylic acid as well as pH-balanced moisturizers

Salicylic acid - Does not lead to crystallization / degradation of SA specifically

Briefs

1 .Scar Prevention Moisturizer -
`@Alex Kaplan`
⁠

Still working on finalizing market research & brief (expected March)

2. Stretch Marks Treatment -
`@Tom Amsterdam`
⁠

Benefits

Instant / short term firming and tightening effects - leveraging optical diffusers

Instant / short term smoothing effects - leveraging film-forming ingredients

Long term effect improving and stretch marks BOTH Striae Rubrae and Striae Albae Stretch Marks

Promotes a Contoured, Toned and Slimmer Belly - Uses actives like peptides, algae, or other to target adipose tissue and cellulite in the belly area to actively firm over time and stimulate collagen and elastin production

Deep Hydration and Plumping - Hydrates, softens and improves texture, with a particular focus on nurturing skin that stretches out during pregnancy (through shea butter, hyaluronic acid, and / or others). Moisturizes without any greasy, tacky feel, designed to be well and quickly absorbed into the skin

Form Factor -

Lightweight cream, easily spreadable, absorbs quickly (non-greasy, non-staining)

Fill Size & Cadence

100ml, 1 month cadence

Daily usage (1-2x/day)

Experience

Light and absorbs quickly

Leaves skin feeling glowing

Seamlessly layers with other skincare products or under makeup (no piling)

Does not burn the eyes

Scent

Light, natural (floral or fruity), include only if non-irritating, pregnancy safe

Claims

Paraben-free, Cruelty-free, Non-comedogenic, Hypo-allergenic, Sulfate-free, Phthalate-free, dyes/synthetic color-free. Suitable for sensitive skin

Pregnancy Safe: all ingredients must be safe for use during pregnancy

Nice To Have:

Natural oils to soothe and hydrate skin (like calendula, sunflower, avocado or others)

Ingredients

Instant optical smoothing effects delivered through light diffusers ingredient (e.g., dimethicone, silica, cellulose, ethylene, mica)

Instant tightening effects delivered through tightening film-forming ingredients (e.g., sodium acryloydimethyl taurate copolymer, pullan, acrylates copolymer)

Vasoconstrictor Firming & Tightening Actives - Must include vasoconstrictors (no caffeine or equivalent) that are pregnancy safe to provide firming/tightening benefits

Targets BOTH Striae Rubrae and Striae Albae Stretch Marks

Uses centella asiatica, glycolic acid (<= 10%), and vitamin E to target both Striae Rubrae and Striae Albae Stretch Marks

3. Acne OTC Treatment -
`@Alex Kaplan`
⁠

Benefits

Clears acne blemishes and prevents new breakouts

Controls oiliness without disrupting the skin barrier

Gently exfoliates the skin’s surface—clears pores, removes dead skin cells, helps uneven skin tone/texture, brightens, reduces appearance of scars

Gentle enough for daily use, even on sensitive skin, with soothing ingredients to mitigate irritation

Formulation parameters

Texture: Sheer weightless serum—not too runny where it slides off hands/face, but not too thick where it is hard to spread. Does not clump. Non-greasy, non-sticky, fast-absorbing texture.

Experience: Light, and absorbs quickly without drying out the skin. Leaves skin feeling moisturized, but not greasy or oily; no residue. Seamlessly layers with other skincare products or under makeup (no piling). Does not burn the eyes.

Must-have ingredients

1-2% Salicylic Acid (can be encapsulated to improve irritation profile or solubility / pH range)

Soothing/hydrating ingredients to counteract irritation and TEWL

Nice-to-have ingredients

Niacinimide: Include, as long as it does not compromise performance of Salicylic Acid

Cosmetic anti-irritants (to hydrate, soothe, and minimize irritation): E.g., allantoin, madecassoside, cica, hyaluronic acid, glycerin, aloe

Plant antioxidants: E.g., green tea, chamomile, willowherb, licorice root, etc.?

Claims

Paraben-free, Cruelty-free, Drying alcohol-free, Fragrance-free, Hypo-allergenic, Sulfate-free, Silicone-free, Phthalate-free, dyes/synthetic color-free

Scent: Neutral (not medicinal nor chemical)

4. Scar Healing + Preventing Treatment -
`@Alex Kaplan`
⁠

Still working on finalizing market research & brief (expected March)

5. Scar Defense Primer -
`@Tom Amsterdam`
⁠

6. Compounded Tretinoin -
`@Akhila Moturu`
⁠

Implementation Plan

Supporting Resources

Stretch Marks Research & Briefs -

Link⁠

⁠

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