Oncologic Diseases

Diagnosis and Treatment of Common Oncologic Diseases

Signalment and Clinical Signs:

Canine:

Boxer, Basset, Rottweiler, Golden Retriever, Bernese Mountain Dog, Cocker Spaniel, St. Bernard, Scottish Terrier, Airedale, Bulldog

Middle-aged to older (6-9 years old)

Feline:

Siamese, FeLV positive

Bimodal (2 years old or 10-12 years old)

Diagnosis:

Cytology (diagnostic in 80-90% of dogs, less for cats)

Histology +/- Immunohistochemistry (IHC)

Polymerase Chain Reaction (PCR) of antigen receptor rearrangements of lymphocytes (PARR)

Clonality Assay

Diagnostic Assessment:

Anatomic Types

Multicentric (80-85% of dogs)

Alimentary - solitary, multifocal or diffuse (30-70% of cats)

Mediastinal (90% of FeLV positive cats)

Extranodal - renal, cutaneous, neural, ocular, etc.

Phenotypic Types (flow cytometry or IHC)

B cell - CD79a (75-80% of dogs)

T cell - CD3

Null (neither B nor T)

Histologic Grade (biopsy in dogs often not performed because most are high grade)

Low

Intermediate

High (80% of dogs, >55% of cats)

Cause:

85%

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